Generation and functional characterization of a multigene-modified NK101 cell line exerting diverse mechanisms of antitumor action
Clonal cell line-based, multigene-modified, off-the-shelf NK cell therapeutics are emerging as the new frontier of adoptive cellular immunotherapy.Here, we utilized a newly established NK cell line, NK101, as a backbone to derive multifaceted killer cells armored Wash Tee with various antitumor modalities through repeated cycles of genetic modifica