GENERATION AND FUNCTIONAL CHARACTERIZATION OF A MULTIGENE-MODIFIED NK101 CELL LINE EXERTING DIVERSE MECHANISMS OF ANTITUMOR ACTION

Generation and functional characterization of a multigene-modified NK101 cell line exerting diverse mechanisms of antitumor action

Clonal cell line-based, multigene-modified, off-the-shelf NK cell therapeutics are emerging as the new frontier of adoptive cellular immunotherapy.Here, we utilized a newly established NK cell line, NK101, as a backbone to derive multifaceted killer cells armored Wash Tee with various antitumor modalities through repeated cycles of genetic modifica

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Period Changes of 23 Field RR Lyrae Stars

The Ship Model secular period behavior of 23 field RR Lyrae stars is studied in order to determine if the observed period changes could be attributed, at least in the mean, to stellar evolution.The sample of stars is subdivided into two Oosterhoff groups based on the metallicity and period-shift.Despite the small sample size, we found a distinct bi

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Different impact of recovery annealing and thermal pressure treatments on the microstructure and mechanical properties of rejuvenated Cu64Zr36 metallic glasses: A molecular dynamics study

The interpenetrating connection of icosahedra network (ICOIN) was termed as structural skeleton, which could quantify the strength and ductility of MGs.The impact of different rejuvenation methods on medium-range order (MRO) alterations was rarely studied.This work employed molecular dynamics simulations to examine the difference in MRO evolution o

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